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Randomized phase III trials of interferon-α with or without bevacizumab in advanced renal cell cancer patients not having prior systemic therapy [Rini et al. 2008c; Escudier et al. 2007c].
| Treatment | PFS | p value | OS | p value |
|---|---|---|---|---|
| AVOREN Study | ||||
| Interferon-α + bevacizumab | 10.2 | 0.0001 | NR | NA |
| Interferon-α | 5.4 | 19.8 | ||
| CALGB 90206 | ||||
| Interferon-α + bevacizumab | 8.5 | 0.0001 | NR | NA |
| Interferon-α | 5.2 | NR | ||
NR, not reached; OS, overall survival; PFS, progression-free survival.
