Figure 2.

Sox10 controls expression of ErbB3. Whole-mount in situ hybridizations of wild-type (a–d), Sox10^Dom/Sox10^Dom (e–l), and ErbB3–/− (m–p) embryos with probes specific for Sox10 (top), and ErbB3 (bottom). Shown are lateral (a,b,e,f,m,n) views of E10.5 embryos and the corresponding vibratome sections (c,d,g,h,o,p) on forelimb levels. Lateral (i,j) and dorsal (k,l) views of Sox10^Dom/Sox10^Dom embryos at E9.0. Arrows in f, j, and l point toward ErbB3-expressing cells close to the neural tube in Sox10^Dom/Sox10^Dom embryos; arrows in c, g, and o point toward the anlage of the primary sympathetic ganglion chain (sy); arrowheads in d, f, h, and j point toward the myotome that also expresses ErbB3. Bars (a,b,e,f,m,n) 1 mm; (c,d,g,h,o,p) 100 μm; (i–l) 300 μm.