Figure 6.

Loss of motoneurons in Sox10^Dom/Sox10^Dom and ErbB3^−/− mutant mice. Sections of the cervical spinal cord of wild-type (a) and Sox10^Dom/Sox10^Dom (b) mutant animals at E18.5 after in situ hybridization with a VAChT specific probe. (c,d) Motoneuron numbers in cervical, thoracic, and lumbar segments of spinal cords obtained from wild-type (blue columns), Sox10^Dom/Sox10^Dom (red columns), and ErbB3^−/− (green columns) mutants at E15.5 (c) and E18.5 (d). Mean numbers of motoneurons per section +/− S.D. are shown (n = 4 embryos for each genotype and developmental stage). Counts were not corrected for neuron size, and the numbers of neurons at different developmental stages are therefore not strictly comparable. Bar (a,b) 100 μm.