Table IV.
Responses by EBMT Criteria and Other Evidence of Activity.
| Category | Tanespimycin dose, mg/m2 |
||||||
|---|---|---|---|---|---|---|---|
| 150 n = 4 | 220 n = 9 | 275 n = 3 | 340 n = 7 | 420 n = 3 | 525 n = 3 | All dose cohorts N = 29 | |
| Minimal response, n (%) | 1 (25) | 0 | 0 | 0 | 0 | 0 | 1 (3) |
| Stable disease, n (%) | 2 (50) | 5 (56) | 3 (100) | 3 (43) | 1 (33) | 1 (33) | 15 (52) |
| Progression of disease, n (%) | 1 (25) | 4 (44) | 0 | 3 (43) | 2 (67) | 1 (33) | 11 (38) |
| Missing, n (%) | 0 | 0 | 0 | 1 (14) | 0 | 1 (33) | 2 (7) |
| Decrease in M protein, n | 1 | 0 | 1 | 2 | 0 | 0 | 4 |
| Decrease in M spike, % | 33 | 11 | 20, 11 | ||||
| Decrease in urinary M protein, % | 41 | 12 | 91, 43 | ||||
EBMT, the European Group for Blood and Marrow Transplantation.