Fig. 4.

Associations between HLA-associated polymorphisms in patient-derived Gag, replication capacities of recombinant viruses encoding patient Gag-protease, and viral load set points. (A) A significant negative correlation between the proportion of host-specific HLA-associated polymorphisms in or adjacent to Gag epitopes and the replication capacities of recombinant viruses encoding Gag-protease. (B) A significant positive correlation between the proportion of host-specific HLA-B-associated polymorphisms present in Gag and viral load set point. (C) Significantly higher viral load set points in patients with protective HLA alleles that have a polymorphism associated with those alleles in Gag (n = 5) versus those that do not (n = 4; Mann-Whitney U test).