Fig. 1.

The adapted virus infects a greater percentage of cells and reaches higher viral titers than the wild-type virus. (A) Naive Lunet-CD81 cells were infected at an MOI of 0.5, and the infections were monitored over time using NS5A staining. Data are representative curves. (B) Naive Lunet-CD81 cells were infected at an MOI of 0.5, and viral titers were followed over time. A representative time course is shown. Data are representative curves. (C) Naive Lunet-CD81 cells were infected at various multiplicities of infection, and the percentage of viable cells was estimated 3 days postinfection. Error bars indicate the standard deviations of data from three assays.