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. 2001 Jan 15;15(2):241–253. doi: 10.1101/gad.840301

Figure 1.

Figure 1

Figure 1

Figure 1

Src251 induces osteopetrosis. (A) Structure of TRAPSrc transgenic constructs. The TRAP promoter, first exon, and intron were fused to the ATG of wild-type (WT) and mutant versions of the chicken c-src gene. (U) Unique region; (SH3) Src homology 3 region; (SH2) Src homology 2 region; (Kinase) kinase domain. Crosses overlay domains containing inactivating mutations. (B) Radiographic analyses of Src251 mice. X-rays, frontal view. Brackets indicate regions that demonstrate increased bone density. (C) Histological analyses of tibia. Sections were stained both with Hematoxylin and Eosin (H&E) and for TRAP activity. (Upper panel) low power (4× magnification). (Lower panel) intermediate power (20×), showing TRAP-positive osteoclasts. (D) Histomorphometric analyses of mice. Genotype is indicated on the X axis. Percentage bone volume (amount of bone matrix as a percentage of the cancellous bone) is indicated on the Y axis. Osteoclasts were counted as TRAP-positive cells.