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. 2001 Jan 15;15(2):241–253. doi: 10.1101/gad.840301

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Copyright © 2001, Cold Spring Harbor Laboratory Press

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Src251 induces apoptosis of intestinal epithelial cells. (A) Histological analyses of large intestine (100×). Arrows indicate apoptotic epithelial cells. (Upper panels) H&E-stained sections; (lower panels) TUNEL staining showing apoptotic cells. (B) Percentage apoptotic large-intestine epithelial cells. Numbers were obtained from 3000 epithelial cells counted in each of two sections. (C) Model for action of Src251. Src251 is a particularly effective dominant-negative molecule because it efficiently blocks interactions of the Src homology protein interaction domains.

Src251 induces apoptosis of intestinal epithelial cells. (A) Histological analyses of large intestine (100×). Arrows indicate apoptotic epithelial cells. (Upper panels) H&E-stained sections; (lower panels) TUNEL staining showing apoptotic cells. (B) Percentage apoptotic large-intestine epithelial cells. Numbers were obtained from 3000 epithelial cells counted in each of two sections. (C) Model for action of Src251. Src251 is a particularly effective dominant-negative molecule because it efficiently blocks interactions of the Src homology protein interaction domains.