Fig. 7.

Antiviral activity of the A3 proteins against PERV and MuLV. 293T cells were infected with VSV-G pseudotyped PERV (A) or VSV-G pseudotyped MuLV (B) that was produced in the presence or absence of the indicated A3 proteins. For each approach, two independent experiments were done, and the results were compared to get a standard deviation. Levels of significance are indicated: *, P < 0.05; **, P < 0.01; ***, P < 0.0001. (C) Immunoblotting to determine the intracellular A3 expression. The cytidine deaminases were detected with an anti-HA or an anti-V5 antibody. An anti-beta-actin antibody served as a loading control.