Fig. 8.

Reovirus growth is significantly decreased in Bax^−/− brains, but transneuronal transport is not impaired. Bax^−/− mice and their littermates were infected with 100 PFU T3D. Brains and eyes were harvested at 9 dpi or later and analyzed for viral titer by plaque assay. Each point represents the average viral titer per animal. The graphs show viral growth in brains of mice (n = 5 each) at 9 dpi from four separate litters (A), viral growth in brains of mice showing seizures in WT mice at 10 to 11 dpi (n = 5; 2 litters) and Bax^−/− mice at dpi 11 to 13 (n = 9; 5 litters) (B), and viral titers in both eyes of WT (n = 5; 5 litters) and Bax^−/− (n = 5; 2 litters) mice at 9 dpi (C). *, P < 0.05; and **, P < 0.005 compared to WT.