Table 2.

Comparison of amino acid sequences of the stem region of E proteins of different flaviviruses^a

^aThe stem region of E protein contains two α-helical domains (EH1 and EH2) and a stretch of CSs in between (60). Sequences of the stem regions of multiple strains of flaviviruses were obtained from GenBank and analyzed. Single-letter amino acid designations are shown, with the numbers above indicating amino acid positions and the numbers beneath indicating the numbers of strains containing such a residue. The residues at the a or d position of the helical wheel are in boldface. Asterisks indicate residues highly conserved among the four DENV serotypes (*) or flaviviruses (**) analyzed. JEV, Japanese encephalitis virus; YFV, yellow fever virus; WNV, West Nile virus.