Table 1.
Various defects detected in postnatal CYP26 mutant mice
| No.
|
Short tail
|
Spina bifida
|
Sirenomelia
|
Deficiency of the external genitalia
|
Anal atresia
|
Horseshoe kidney
|
Skeletal analysis
|
|---|---|---|---|---|---|---|---|
| 1 | X | X | X (aplasia) | X | X | X | 2 |
| 2 | X | X | X | X | X | X | 1 |
| 3 | X | X | X | X | X | X | 3 |
| 4 | X | X | X | X | X | X | 4 |
| 5 | X | X | X | X | X | X | ND |
| 6 | X | X | X | X | X | X | ND |
| 7 | X | X | — | — | — | X | 5 |
| 8 | X | X | — | — | — | — | ND |
| 9 | X | X | — | — | — | — | ND |
| 10 | X | — | — | — | — | — | ND |
Ten CYP26 mutant mice obtained postnataly were examined. (X) Phenotype observed; (−) phenotype not observed; (ND) not determined. The mice referred to as 1 to 5 correspond to the animals 1 to 5 in Fig. 5G.