Table 2.
Sample type | Patient no. | Sample (nb) | P value for sequence comparison with indicated samplea (nb) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
JD 01 (3) | JD 02 (4) | JD 03 (14) | JD 04 (6) | JD 05 (8) | JD 06 (7) | BD 02 (8) | BD 05 (3) | ||||
Plasma | 116 | PR 01 (3) | 1 NS | 0.2740 NS | 0.2040 NS | 0.5650 NS | 0.5050 NS | 0.4040 NS | 0.4500 NS | 0.9030 NS | |
PR 06 (PIc) (13) | 0.001** | 0.001** | 0*** | 0*** | 0*** | 0*** | 0*** | 0.002** | |||
PR 07 (PI) (4) | 0.029* | 0.026* | 0*** | 0.0020** | 0.0040** | 0.0020** | 0.0020** | 0.0220* | |||
JD 01 (12) | JD 02 (21) | JD 03 (14) | JD 04 (18) | JD 05 (11) | BD 01 (19) | BD 02 (17) | BD 03 (8) | BD 04 (4) | |||
134 | PR 01 (23) | 0*** | 0*** | 0*** | 0*** | 0*** | 0*** | 0*** | 0*** | 0.0170* | |
PR 05 (PI) (8) | 0*** | 0*** | 0*** | 0*** | 0*** | 0*** | 0*** | 0*** | 0.0130* | ||
JD 01 (3) | JD 02 (4) | JD 03 (14) | JD 04 (6) | ||||||||
140 | PR 01 (2) | 0.0210* | 0.0070** | 0.1120 | 0.0110* | ||||||
PR 04 (PI) (17) | 0*** | 0*** | 0*** | 0*** | |||||||
JD 01 (3) | JD 02 (4) | JD 03 (14) | JD 04 (6) | JD 05 (8) | JD 06 (7) | ||||||
PBMCs | 116 | BD 02 (8) | 0.0210* | 0.0020* | 0.00*** | 0.00*** | 0.00*** | 0.00*** | |||
BD 05 (3) | 0.0610 NS | 0.0290* | 0.0030** | 0.0120* | 0.0300* | 0.0100* | |||||
JD 01 (12) | JD 02 (21) | JD 03 (14) | JD 04 (18) | JD 05 (11) | |||||||
134 | BD 01 (19) | 0.6070 NS | 0.0090** | 0.3050 NS | 0.6710 NS | 0.6720 NS | |||||
BD 02 (17) | 0.6830 NS | 0.0140* | 0.5340 NS | 0.9020 NS | 0.4700 NS | ||||||
BD 03 (8) | 0.8370 NS | 0.1670 NS | 0.5640 NS | 0.7220 NS | 0.4640 NS | ||||||
BD 04 (4) | 0.5790 NS | 0.8240 NS | 0.7130 NS | 0.6800 NS | 0.5300 NS |
Numbers represent P values from the gene flow analysis from the DnaSp software package using 1,000 permutations. Probability was obtained by the permutation test with 1,000 replicates. NS, not significant; *, 0.01 < P < 0.05; **, 0.001 < P < 0.01; ***, P < 0.001. JD, jejunal proviral sequences; BD, PBMC proviral sequences; PR, plasma viral sequences. Numbers following tissue type indicate time points as shown in Fig. 1.
n, total number of clonal sequences in each category.
PI, post-therapy interruption time point.