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Model of MVM-induced NE disruption. MVM induces disruption of the nuclear membranes by a mechanism that does not involve viral PLA2 activity (1). Previously cleaved, activated caspases in the cytoplasm gain access to the nucleus (2), where they cleave B-type lamins (3). This cleavage is necessary for sustained disruption of the NE, which in turn mediates nuclear entry of the MVM capsid and possibly other cellular proteins required by the virus for replication (4).
