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. 2011 May;85(10):4667–4672. doi: 10.1128/JVI.00047-11

Fig. 2.

Fig. 2.

Pathogenicity of oseltamivir-resistant H5N1 virus in ferrets. (A to D) Body temperature of ferrets infected with oseltamivir-resistant H5N1 virus. Three ferrets per group were intranasally infected with 2.5 × 105 PFU of HN30408 or HN30408-N294S virus. Animals were mock treated (A and C) or treated with oseltamivir phosphate (25 mg/kg) orally (B) or zanamivir (5 mg/kg) intranasally (D) twice daily for 5 days beginning at 2 h postinfection. The body temperatures of infected ferrets were monitored daily for 10 days. (E to H) Body weights of ferrets infected with oseltamivir-resistant H5N1 virus. The body weights of ferrets infected with HN30408 or HN30408-N294S virus and mock treated (E and G) or treated with oseltamivir phosphate (F) or zanamivir (H) were monitored daily for 10 days. Error bars indicate standard deviations.