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Pathogenicity of oseltamivir-resistant VN1203 viruses in ferrets. Three ferrets per group were intranasally infected with 2.5 × 105 PFU of wild-type VN1203, VN1203-H274Y, or VN1203-N294S virus. The body temperatures (A) and weights (B) of infected ferrets were monitored daily for 10 days. Nasal washes were also collected from infected ferrets on days 1, 3, 6, and 9 postinfection and subjected to plaque assays in MDCK cells (C). Error bars indicate standard deviations.
