Table 1.
Organ | Virus titer (log10 PFU/g) of HN30408-infected untreated animals used for: |
|
---|---|---|
Oseltamivir experiments | Zanamivir experiments | |
Brain | 6.0 | 6.3 |
Lung | 5.1 | 5.6 |
Heart | 3 | 4.7 |
Spleen | 3.6 | 2.3 |
Liver | 5.0 | 5.6 |
Kidney | <1 | <1 |
Colon | <1 | <1 |
One each of the HN30408 virus-infected, mock-treated ferrets used for the oseltamivir and zanamivir treatment experiments died on days 5 and 4 postinfection, respectively. Virus recovered from the various organs of these ferrets was titrated by use of plaque assays in MDCK cells.