Table 2.
Virus titers in organs of VN1203 virus- and VN1203 virus variant-infected dead ferretsa
| Organ | Virus titer (log10 PFU/g) of animals infected with: |
||
|---|---|---|---|
| Wild-type VN1203 | VN1203-H274Y | VN1203-N294S | |
| Brain | 5.7 | 1.7 | 3.7 |
| Lung | 5.6 | 3.1 | 3.8 |
| Spleen | <1.7 | <1.7 | <1.7 |
| Liver | 5.2 | <1.7 | 3.9 |
| Colon | <1.7 | <1.7 | 4.1 |
a
One each of the wild-type VN1203-, VN1203-H274Y-, and VN1203-N294S virus-infected ferrets died on days 7, 8, and 8 postinfection, respectively. Virus recovered from the various organs of these ferrets was titrated by use of plaque assays in MDCK cells.