Fig. 1.

Schematic representation of NS3. The two cytoplasmic domains (N terminal and C terminal), the two transmembrane domains (TM), and the extracellular domain (EC) are indicated. Numbers above indicate amino acid position according to the NS3 amino acid sequence. The glycosylation site at asparagine position 150 is also shown (arrow). The changes in either the first or the second methionine residue introduced by site-directed mutagenesis are shown in the lower panel; dots indicate no change, and dashes indicate absence of expressed residues.