Table 4.
IC50 values of six rhesus monkey quaternary structure-specific MAbs against a selected panel of 14 HIV-1 clade A, B, and C Env pseudoviruses sensitive to MAb 2909, either with wild-type Env or with the N160K or K160N (for SF162) mutation
| Virus clade (no. of wild-type viruses) and designation | IC50 (μg/ml) of: |
|||||||
|---|---|---|---|---|---|---|---|---|
| 2909 | PG16 | 2.2G | 2.3E | 2.5B | 1.8E | LW10E | 1.6F | |
| Clade B (5) | ||||||||
| SF162 | 0.015 | >50 | <0.003 | 0.029 | <0.003 | <0.003 | <0.003 | <0.003 |
| SF162_K160N | >50 | 0.002 | >50 | >50 | >50 | >50 | >50 | >50 |
| AC10.29 | >50 | 0.009 | >50 | >50 | >50 | >50 | >50 | >50 |
| AC10.29_N160K | 0.001 | >50 | 0.009 | 0.272 | >50 | 5.4 | >50 | 0.022 |
| 7165.18 | >50 | 0.426 | >50 | >50 | >50 | >50 | >50 | >50 |
| 7165.18_N160K | 0.017 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| WITO.33 | >50 | 0.002 | >50 | >50 | >50 | >50 | >50 | >50 |
| WITO.33_N160K | 0.105 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| YU2 | >50 | 0.258 | >50 | >50 | >50 | >50 | >50 | >50 |
| YU2_N160K | 0.492 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| Clade A (5) | ||||||||
| Q259.17 | >50 | 0.030 | >50 | >50 | >50 | >50 | >50 | >50 |
| Q259.17_N160K | 0.006 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| Q23.17 | >50 | 0.001 | >50 | >50 | >50 | >50 | >50 | >50 |
| Q23.17_N160K | 0.047 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| KNH1209.18 | >50 | 0.283 | >50 | >50 | >50 | >50 | >50 | >50 |
| KNH1209.18_N160K | 0.151 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| DJ263.8 | >50 | 8.2 | >50 | >50 | >50 | >50 | >50 | >50 |
| DJ263.8_N160K | 0.620 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| BS208.B1 | >50 | 0.003 | >50 | >50 | >50 | >50 | >50 | >50 |
| BS208.B1_N160K | 1.1 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| Clade C (4) | ||||||||
| ZM233.6 | >50 | 0.001 | >50 | >50 | >50 | >50 | >50 | >50 |
| ZM233.6_N160K | 0.004 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| Du422.1 | >50 | 0.042 | >50 | >50 | >50 | >50 | >50 | >50 |
| Du422.1_N160K | 0.843 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| CAP45.G3 | >50 | 0.002 | >50 | >50 | >50 | >50 | >50 | >50 |
| CAP45.G3_N160K | 2.17 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| ZM249.1 | >50 | 0.009 | >50 | >50 | >50 | >50 | >50 | >50 |
| ZM249.1_N160K | 3.73 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |