Fig. 1.

Profiles of resistance to CCR5 inhibitors. Env-pseudotyped luciferase reporter viruses were used to infect JC53 cells in the presence of increasing concentrations of MVC (A and B), VVC (C), or T-20 (D) as described in Materials and Methods. Virus inhibition curves were constructed using Prism, version 4.0c (GraphPad Software), as described in Materials and Methods. The data shown are means of triplicates (error bars represent standard deviations) and are representative of 3 (A, C, and D) or 5 (B) independent experiments.