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Isotypes and epitopes of the monoclonal antibodies generated in this studya
| Antibody | Isotype | Epitope |
|---|---|---|
| W123 | IgG2b | 145-WEDRYYREN-153 |
| W187 | IgG2b | WGQPHGG (octarepeat motif) |
| W226 | IgG1 | 145-WEDRYYREN-153 |
| W261 | IgG1 | Unknownb |
| W756 | IgG2a | 145-WEDRYYREN-153 |
| W827 | IgG1 | 145-WEDRYYREN-153 |
Amino acids are numbered according to the hamster prion protein sequence.
The epitope of W261 is thought to be a conformational epitope located in the PK-resistant core of PrPsc.
