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Inhibition of G312V and A204E variants by TAK779
| Clone | Residue change | % inhibitiona |
|---|---|---|
| Q23-17 | G312V | 100 ± 0 |
| A204E | 98 ± 1 | |
| QF495.A3 | G312V | 99 ± 1 |
| A204E | 100 ± 0 | |
| MG505.H3 | G312V | 100 ± 0 |
| A204E | 100 ± 0 | |
| BG505.B1 | G312V | 100 ± 0 |
| A204E | 99 ± 0 | |
| Q259.D2.26 | G312V | 100 ± 0 |
| A204E | 100 ± 0 | |
| SF162P3 | 100 ± 0 | |
| NL-DT5R | 15 ± 21 |
Percent inhibition of luciferase activity in cells treated with 1 μM TAK779, compared to untreated cells (averages ± standard deviations from two independent experiments).
