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. 2011 May;85(9):4157–4166. doi: 10.1128/JVI.02449-10

Fig. 5.

Fig. 5.

HCV NS5A modulates Stat-1 and suppresses C4 promoter activation. (A) Stat-1 activation was examined by transient transfection of HCV NS5A into Huh7 cells. The inhibitory effect of HCV NS5A on IFN-γ-induced Stat-1 phosphorylation is shown. pStat-1, phosphorylated Stat-1. (B) C4 promoter activity was examined in Stat-1 knockout (KO) (U3A) cells. IFN-γ treatment did not induce C4 promoter activation compared to HT1080 cells. (C) Knockdown of Stat-1 by siRNA attenuates IFN-γ-induced C4 mRNA expression in Huh7 cells.