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Cartoon model for influenza virus RNP trafficking. RNPs are replicated within the nucleus and exported via cellular Crm1 and viral NEP and M1 proteins. They initially concentrate at the pericentriolar recycling endosome (RE) adjacent to the microtubule organizing center (MTOC) through interactions with Rab11. Subsequently, they traffic along the microtubule network toward the cell periphery and plasma membrane (PM) on Rab11-positive cargo vesicles.
