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Binding and neutralization of selected Fabs
| Fab clonea | Poliovirus serotype bound in ELISAb | In vitro neutralizing activityc |
|---|---|---|
| A7 | 1 | − |
| A12 | 1 | + |
| B7 | 1 | − |
| C1 | 1 | − |
| D2 | 1 | − |
| D4 | 1 | − |
| E1 | 1 | − |
| G1 | 1 | − |
| H2 | 1 | + |
| A1 | 2 | − |
| A6 | 2 | + |
| B2 | 2 | + |
| G6 | 3 | − |
| B10 | 3 | + |
| A2 | 3 | + |
| E3 | 3 | + |
| C2 | 3 | − |
| C10 | 3 | + |
| F5 | 3 | − |
Fab clones were defined as clones with distinct VH and VL sequences.
Binding to specific types of Sabin polioviruses in ELISA by soluble Fabs.
Neutralizing activity was measured by PRNT.
