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. 2011 Jun;85(12):5757–5763. doi: 10.1128/JVI.02690-10

Fig. 2.

Fig. 2.

Viral loads of SMs vary by mode of SIV transmission and age. (A) Viral loads in SMs infected with SIV by presumptive MTIT and non-MTIT were measured as SIV RNA copies per ml of serum or plasma. Serial measurements during the first year of life (≤1 year of age; n = 26) and as adults (≥6 years of age; n = 19) were performed for the 11 SIV-infected SMs with presumptive MTIT. For comparison, viral loads of 105 adult SMs infected with SIV by non-MTIT are shown. Measurements below the limit of detection for the assay are plotted at 80 SIV RNA copies/ml. Circles represent individual data points, and horizontal lines indicate geometric means. Mixed-effects models were used to determine statistical significance. (B) Direct comparison of the viral loads measured in seven SMs infected with SIV by presumptive MTIT for which samples were available at both ≤1 year of age and at ≥6 years of age. Individual animals are color coded. Measurements below the limit of detection for the assay are plotted at 80 SIV RNA copies/ml. Circles represent individual data points, and horizontal lines indicate geometric means. (C) Representative examples of SIV serology, viremia, and CD4+ T-cell counts over time in two SMs infected with SIV by presumptive MTIT and two infected with SIV by non-MTIT.