Table 1.
Clinical characteristics of patients with chronic HIV-1–HCV coinfection treated with pegIFN-α–RBV therapy
| Parameter | SVR | Treatment failure | P valuea |
|---|---|---|---|
| No. (%) of samples | 19 (34) | 37 (66) | |
| Mean patient age, yr (range) | 40.9 (32–53) | 39.4 (23–50) | 0.3680 |
| No. (%) of patients with IL-28B risk allele rs12979860 | 2 (11) | 24 (65) | 0.0002 |
| No. (%) of: | 0.6936 | ||
| Females | 5 (26) | 8 (22) | |
| Males | 14 (74) | 29 (78) | |
| No. (%) with HCV subtype: | 1.0000 | ||
| 1a | 13 (68) | 25 (68) | |
| 1b | 6 (32) | 12 (32) | |
| Mean CD4+ cell count/μl (range) | 553 (309–1186) | 546 (265–1165) | 0.7423 |
| Mean ALT activity (U/liter) (range) | 77.1 (13–208) | 78.9 (15–239) | 0.7033 |
| Mean AST activity (U/liter) (range) | 48.0 (19–89) | 55.2 (24–157) | 0.4516 |
| Mean HCV RNA level (log10 IU/ml) (range) | 5.75 (3.37–7.11) | 6.25 (5.04–7.10) | 0.0112 |
| No. (%) of patients with undetectable HIV-1 RNA (<50 copies/ml) | 15 (79) | 30 (81) | 1.0000 |
a
Age, Mann-Whitney U test; IL-28B genotype, Fisher's exact test; gender, Fisher's exact test; HCV subtype, Fisher's exact test; CD4+T cell count, Mann-Whitney U test; ALT (alanine aminotransferase) and AST (aspartate aminotransferase), Mann-Whitney U test; HCV RNA level, unpaired t test; undetectable HIV-1 RNA, Fisher's exact test.