Table 3.
Therapeutic effects of 3-day BCN L-1077 treatments, of various concentrations, against a mixed infection of Campylobacter jejuni and Salmonella Enteritidis 92 Rifr in 43-day-old broilersa
| Chicken group (conditions) | Broiler | BCN dose (mg/bird) | Log10 CFU/g organ homogenate (after treatment) |
||||
|---|---|---|---|---|---|---|---|
| Lactic acid bacteria in cecal content |
C. jejuni |
S. Enteritidis |
|||||
| Liver | Spleen | Liver | Spleen | ||||
| Control group (commercial feed; bacteriocin-free water) | 1 | 0 | 6.79 | 4.86 | 8.65 | 8.60 | 8.60 |
| 2 | 6.79 | 4.26 | 8.08 | 8.49 | 8.46 | ||
| 3 | 8.57 | 4.80 | 8.56 | 7.90 | 8.28 | ||
| 4 | 8.45 | 7.48 | 8.38 | 7.85 | 8.36 | ||
| 5 | 8.11 | 5.26 | 8.46 | 8.52 | 8.59 | ||
| 6 | 8.40 | 7.36 | 8.32 | 8.60 | 8.43 | ||
| Avg (no. of birds averaged) | 7.85 (6) | 6.96 (6) | 8.45 (6) | 8.41 (6) | 8.46 (6) | ||
| Exptl group 1 (commercial feed; 25 mg bacteriocin L-1077/liter) | 7 | 21.3 | 8.15 | NDb | ND | ND | 4.61 |
| 8 | 8.15 | ND | 4.15 | 4.23 | ND | ||
| 9 | 8.76 | ND | 3.81 | ND | ND | ||
| 10 | 7.56 | ND | ND | ND | ND | ||
| 11 | 8.60 | ND | ND | ND | ND | ||
| 12 | 7.30 | ND | ND | ND | ND | ||
| 13 | 8.30 | ND | 2.76 | ND | ND | ||
| 14 | 7.28 | ND | 2.60 | ND | ND | ||
| Avg (no. of birds averaged) | 8.28 (8) | ND (8) | ND (4), 2.69 (2), 3.81 (1), 4.15 (1) | ND (7), 4.23 (1) | ND (7), 4.61 (1) | ||
| Exptl group 2 (commercial feed and water with 12.5 mg BCN L-1077/liter) | 15 | 10.9 | 8.46 | ND | ND | 3.43 | ND |
| 16 | 7.60 | ND | ND | ND | ND | ||
| 17 | 8.95 | ND | ND | ND | ND | ||
| 18 | 8.81 | ND | 2.81 | ND | ND | ||
| 19 | 8.04 | ND | ND | ND | ND | ||
| 20 | 6.85 | ND | ND | ND | ND | ||
| 21 | 7.77 | ND | ND | ND | 1.95 | ||
| 22 | 8.08 | ND | 2.34 | ND | ND | ||
| Avg (no. of birds averaged) | 8.43 (8) | ND (8) | ND (6), 2.63 (2) | ND (7), 3.43 (1) | ND (7), 1.95 (1) | ||
| Exptl group 3 (commercial feed and water with 6.25 mg BCN L-1077/liter) | 23 | 5.5 | 7.30 | ND | ND | ND | ND |
| 24 | 8.11 | ND | ND | ND | ND | ||
| 25 | 8.69 | ND | ND | ND | ND | ||
| 26 | 6.52 | ND | 3.08 | ND | ND | ||
| 27 | 8.60 | ND | 4.11 | 4.23 | 4.28 | ||
| 28 | 9.26 | ND | 3.34 | 4.46 | 4.43 | ||
| 29 | 8.30 | ND | 3.38 | 4.32 | 4.23 | ||
| 30 | 7.83 | ND | ND | 4.32 | 4.15 | ||
| Avg (no. of birds averaged) | 8.59 (8) | ND (8) | ND (4), 3.28 (3), 4.11 (1) | ND (4), 4.34 (4) | ND (4), 4.28 (4) | ||
a
All birds were commercially colonized with nonspecified C. jejuni.
b
ND, none detected; detection limit of >100 cells.