Table 2.
Presence of GIs and phage regions of CFT073 in different UTI isolates
| Island name | Common name | CDSs in island | Virulence/fitness gene(s) within islands | No. of CDSs represented on chip | % of isolates carrying island in disease categorya: |
Pc |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| Urosepsis (15) | Pyelonephritis (8) | Cystitis (9) | ABU (13) | All | Upper vs. lower | |||||
| PAI-CFT073-aspV | PAI-IIICFT073 | c0253-c0368 | fpbABCD, cdiA, picU, tosCBDA, vat | 83 | 40 (6) | 44 (4) | 44 (4) | 23 (3) | 0.602 | 0.542 |
| φ-CFT073-b0847 | c0932-c0979 | 42 | 13 (2) | 0 (0) | 0 (0) | 31 (4) | 0.137 | 0.414 | ||
| PAI-CFT073-serX | c1165-c1293 | mchBCDEF, sfa/foc, iroBCDEN, flu | 102 | 33 (5) | 33 (3) | 22 (2) | 23 (3) | 0.835 | 0.514 | |
| φ-CFT073-potB | c1400-c1475 | 51 | 47 (7) | 56 (5) | 33 (3) | 38 (5) | 0.670 | 0.373 | ||
| φ-CFT073-ycfD | c1481-c1507 | 14 | 7 (1) | 0 (0) | 11 (1) | 0 (0) | 0.803 | 1.000 | ||
| PAI-CFT073-icdA | c1518-c1601 | sitABCD | 74 | 80 (12) | 56 (5) | 44 (4) | 31 (4) | 0.060 | 0.017 | |
| PAI-CFT073-serU | c2392-c2416 | tcpC | 19 | 60 (9) | 33 (3) | 0 (0) | 8 (1) | 0.002 | 0.001 | |
| PAI-CFT073-asnT | HPICFT073 | c2418-c2436 | fyuA | 15 | 100 (15) | 78 (7) | 67 (6) | 69 (9) | 0.046 | 0.022 |
| GI-CFT073-asnW | c2449-c2475 | pks | 26 | 67 (10) | 44 (4) | 33 (3) | 38 (5) | 0.363 | 0.139 | |
| GI-CFT073-cobU | c2482-c2528 | hma, fpbABCD_2 | 37 | 93 (14) | 44 (4) | 56 (5) | 38 (5) | 0.011 | 0.033 | |
| φ-CFT073-smpB | c3143-c3206 | 49 | 20 (3) | 11 (1) | 44 (4) | 31 (4) | 0.475 | 0.189 | ||
| PAI-CFT073-metV | c3385-c3410 | hcp, clpB, c3405 to c3409 | 25 | 100 (15) | 56 (5) | 33 (3) | 38 (5) | 0.000 | 0.001 | |
| PAI-CFT073-pheV | PAI-ICFT073 | c3556-c3698 | sisA, hlyA, pap, iha, sat, iutA, iucABCD, flu, kpsTM | 124 | 33 (5) | 56 (5) | 33 (3) | 15 (2) | 0.182 | 0.208 |
| GI-CFT073-selC | c4491-c4581 | sisB | 70 | 33 (5) | 11 (1) | 0 (0) | 0 (0) | 0.030 | 0.022 | |
| PAI-CFT073-pheU | PAI-IICFT073 | c5143-c5216 | pap_2 | 61 | 53 (8) | 22 (2) | 0 (0) | 8 (1) | 0.008 | 0.004 |
| GI-CFT073-leuXb | c5371-c5386 | 15 | 33 (5) | 22 (2) | 22 (2) | 15 (2) | 0.746 | 0.491 | ||
a
Percentage of isolates predicted to carry the islands (isolates which filtered more than 2/3 of the island CDSs present). The actual number of isolates predicted to carry the island is in parentheses.
b
The boundary of GI-CFT073-leuX was redefined as c5371-c5386 based on comparisons with E. coli MG1655 and UPEC 536.
c
P values below 0.05 are indicated in bold.