Table 3.
Presence of prototypical GIs and phage regions of CFT073 in different UTI E. coli isolates based on phylogenetic group
| Island name | % of isolates carrying island in phylogenetic groupa: |
P |
% of isolates carrying island among B2 isolates in disease categorya: |
Pc |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| B2 (29) | D (8) | B1 (6) | A (2) | All | B2 vs. others | Urosepsis (15) | Pyelonephritis (5) | Cystitis (4) | ABU (5) | Commensalsb (2) | All | Upper vs. lower | |
| PAI-CFT073-aspV | 59 (17) | 0 (0) | 0 (0) | 0 (0) | 0.001 | 0.000 | 40 (6) | 80 (4) | 100 (4) | 60 (3) | 0 (0) | 0.134 | 0.234 |
| φ-CFT073-b0847 | 7 (2) | 13 (1) | 50 (3) | 0 (0) | 0.050 | 0.166 | 13 (2) | 0 (0) | 0 (0) | 0 (0) | 50 (1) | 1.000 | 1.000 |
| PAI-CFT073-serX | 45 (13) | 0 (0) | 0 (0) | 0 (0) | 0.013 | 0.001 | 33 (5) | 60 (3) | 50 (2) | 60 (3) | 0 (0) | 0.568 | 0.688 |
| φ-CFT073-potB | 41 (12) | 88 (7) | 17 (1) | 0 (0) | 0.018 | 0.755 | 47 (7) | 60 (3) | 0 (0) | 40 (2) | 0 (0) | 0.395 | 0.234 |
| φ-CFT073-ycfD | 3 (1) | 0 (0) | 17 (1) | 0 (0) | 0.356 | 1.000 | 7 (1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1.000 | 1.000 |
| PAI-CFT073-icdA | 76 (22) | 38 (3) | 0 (0) | 0 (0) | 0.000 | 0.000 | 80 (12) | 80 (4) | 50 (2) | 80 (4) | 50 (1) | 0.748 | 0.642 |
| PAI-CFT073-serU | 45 (13) | 0 (0) | 0 (0) | 0 (0) | 0.013 | 0.001 | 60 (9) | 60 (3) | 0 (0) | 20 (1) | 0 (0) | 0.109 | 0.020 |
| PAI-CFT073-asnT | 100 (29) | 88 (7) | 0 (0) | 50 (1) | 0.000 | 0.000 | 100 (15) | 100 (5) | 100 (4) | 100 (5) | 100 (2) | 1.000 | 1.000 |
| GI-CFT073-asnW | 76 (22) | 0 (0) | 0 (0) | 0 (0) | 0.000 | 0.000 | 67 (10) | 80 (4) | 75 (3) | 100 (5) | 0 (0) | 0.617 | 0.382 |
| GI-CFT073-cobU | 93 (27) | 0 (0) | 0 (0) | 50 (1) | 0.000 | 0.000 | 93 (14) | 80 (4) | 100 (4) | 100 (5) | 50 (1) | 0.741 | 1.000 |
| φ-CFT073-smpB | 14 (4) | 63 (5) | 50 (3) | 0 (0) | 0.013 | 0.014 | 20 (3) | 0 (0) | 0 (0) | 20 (1) | 0 (0) | 0.889 | 1.000 |
| PAI-CFT073-metV | 97 (28) | 0 (0) | 0 (0) | 0 (0) | 0.000 | 0.000 | 100 (15) | 100 (5) | 75 (3) | 100 (5) | 50 (1) | 0.138 | 0.310 |
| PAI-CFT073-pheV | 34 (10) | 63 (5) | 0 (0) | 0 (0) | 0.080 | 1.000 | 33 (5) | 60 (3) | 25 (1) | 20 (1) | 0 (0) | 0.640 | 0.431 |
| GI-CFT073-selC | 21 (6) | 0 (0) | 0 (0) | 0 (0) | 0.499 | 0.075 | 33 (5) | 20 (1) | 0 (0) | 0 (0) | 50 (1) | 0.423 | 0.137 |
| PAI-CFT073-pheU | 34 (10) | 13 (1) | 0 (0) | 0 (0) | 0.293 | 0.067 | 53 (8) | 40 (2) | 0 (0) | 0 (0) | 0 (0) | 0.069 | 0.011 |
| GI-CFT073-leuX | 38 (11) | 0 (0) | 0 (0) | 0 (0) | 0.053 | 0.004 | 33 (5) | 40 (2) | 50 (2) | 40 (2) | 0 (0) | 0.942 | 0.694 |
a
Percentage of isolates predicted to carry the islands (isolates which filtered more than 2/3 of the island CDSs present). Values in parentheses are the actual number of isolates predicted to carry the island.
b
Probe sequences were used in BLAST analysis against the two sequenced B2 strains SE15 and ED1a.
c
P values below 0.05 are indicated in bold.