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. 2011 Jul;85(13):6657–6668. doi: 10.1128/JVI.00302-11

Fig. 4.

Fig. 4.

LGP2 inhibits RABV-triggered type 1 IFN and inflammatory responses in the infected NS. (A) IFN-β, OAS1, and IL-6 transcripts in the spinal cords (upper row) and brains (lower row) of WT and LGP2 TG mice sacrificed on day 8 and day 11 p.i. (n = 7 or 8) were quantified by qRT-PCR and normalized to values obtained for mock-infected tissues (value set to 1). Data are presented as means and SEM (*, P ≤ 0.05; **, P ≤ 0.005; ***, P ≤ 0.0005). (B) Inflammatory bioarray analysis of markers of IFN-mediated and inflammatory responses (IL-12p40p70, CXCL9, TIMP-1, sTNF-R1, CCL5, IL-13, CXCL11, CCL2, and IL-6) in NI and RABV-infected brains of WT and LGP2 TG mice at days 8 and 11 p.i. (n = 2) (normalized value = 100 for NI WT mouse brain). The results are representative of two independent experiments.