Fig. 7.

Shift in IL-10-producing CD4 T cell populations during viral pathogenesis. (A) Representative density plots, gated on CD45^hi CD4⁺ T cells, depicting CD25 expression and intracellular Foxp3 expression at days (d) 10 and 21 p.i. (B) Representative density plots, gated on CD45^hi CD4⁺ T cells, depicting IL-10-producing CD25⁺ and CD25⁻ cells at days 10 and 21 p.i. (C) Relative percentages of CD25⁺ cells within CD4⁺ T cells. (D) Relative percentages of CD25⁺ IL-10⁺ (filled bars) and CD25⁻ IL-10⁺ (shaded bars) cells within CD4⁺ T cells at various times p.i. Samples were pooled from 4 to 6 mice at each time point. Results are means ± SEM from 4 separate experiments. **, P < 0.005.