Fig. 4.

Normal peripheral humoral responses in CXCR3^−/− mice. (A) Frequencies of virus-specific and total IgG-secreting ASC in CLN measured by ELISPOT assay. (B) ELISPOT analysis of virus-specific ASC in bone marrow, representative of three experiments with pooled samples from 4 to 6 mice/time point. (C) Virus-specific IgG2a and virus neutralizing Ab in sera of infected WT and CXCR3^−/− mice. IgG2a titers are the average of triplicate samples from three individual mice per time point. Neutralizing titers from pooled serum (n = 3 to 5 mice/time point/experiment) reflect the average titers from two to three experiments.