Fig. 7.

CXCR3 deficiency impairs virus control during persistence independent of T cells. (A) Accumulation of total CD8⁺, Db-S510 tetramer-positive CD8⁺ (striped portion), and CD4⁺ T cells per spinal cord as assessed by flow cytometry at day 7 p.i. Data are from 4 mice/group and are representative of three experiments. (B) Average IFN-γ protein ± standard errors of the means in spinal cords of virus-infected mice (n = 3 per time point). (C) Average expression levels of IL-21 mRNA in spinal cords relative to GAPDH ± standard errors of the means from three individual mice/time point. Panels D and E show viral mRNA and infectious virus levels, respectively, in spinal cords of infected mice. The dashed line indicates the limit of detection.