Table 1.
RVFV components and their role in infection and pathology
Protein | Mol wt | Genome segment | Role in pathogenesis | Reference(s) |
---|---|---|---|---|
Viral RNA polymerase | 244 | L | RNA replication and viral RNA transcription | 40, 68 |
Gn/Gc | 59/55 | M | Mediates virus entry into cells through receptors; contributes to the assembly process and likely interacts with N protein | 16, 39 |
NSm1/NSm2 | 78/14 | M | Suppresses virus-induced apoptosis | 67 |
N | 27 | S | Induces humoral and T-cell immunity response | 36, 41, 42 |
NSs | 31 | S | Interferon antagonist: limits IFN-mediated host antiviral responses, inhibiting cellular transcription and degrading protein kinase PKR; interacts with specific DNA regions of the host genome, inducing chromosome cohesion and segregation defects | 10, 24, 30, 38, 45 |