Skip to main content
. 2011 Jul;85(13):6098–6105. doi: 10.1128/JVI.02641-10

Table 1.

RVFV components and their role in infection and pathology

Protein Mol wt Genome segment Role in pathogenesis Reference(s)
Viral RNA polymerase 244 L RNA replication and viral RNA transcription 40, 68
Gn/Gc 59/55 M Mediates virus entry into cells through receptors; contributes to the assembly process and likely interacts with N protein 16, 39
NSm1/NSm2 78/14 M Suppresses virus-induced apoptosis 67
N 27 S Induces humoral and T-cell immunity response 36, 41, 42
NSs 31 S Interferon antagonist: limits IFN-mediated host antiviral responses, inhibiting cellular transcription and degrading protein kinase PKR; interacts with specific DNA regions of the host genome, inducing chromosome cohesion and segregation defects 10, 24, 30, 38, 45
HHS Vulnerability Disclosure