Table 2.
Novel viral virion proteinsa
| Protein | Common name | Proposed function(s) | Mass (kDa) | Detection by nLC-ESI/MALDIb | Presence in HSV-1c |
|---|---|---|---|---|---|
| pUL8 | DNA replication, helicase/primase complex | 71 | +/− | − | |
| pUL20 | Viral egress | 17 | +/+ | + | |
| pUL32 | DNA packaging, capsid precursor | 52 | +/− | − | |
| pUL40 | RR2 | Ribonucleotide reductase | 34 | +/+ | − |
| pUL42 | DNA replication, viral polymerase subunit | 40 | +/− | − | |
| pUL50 | dUTPase | dUTPase | 29 | +/+ | + |
| pUS1 | RSp40/ICP22 | Gene regulation | 40 | +/− | − |
a
Only proteins detected in virions following proteinase K treatment are shown.
b
+/+, detected by both nLC-ESI and MALDI-based proteomic workflows; +/−, identified only by nLC-ESI workflow.
c
As determined by MS (83).