Fig. 5.
Virulence and course of disease in ferrets. Groups of three or four animals were infected intranasally with 105 TCID50 of either 5804P, 58MOS, or OS. (A) Virulence index. Each box represents one animal, and black represents the highest (2), gray an intermediate (1), and white the lowest (0) score for the respective criteria, as detailed in Materials and Methods. (B) Rectal temperatures were recorded daily. (C) Leukopenia in animals infected with the different viruses. Leukocyte counts at day 0 postinfection (p.i.) were set as 100% for each animal. (D) The course of cell-associated viremia is shown as the log10 of the virus titer per 106 PBMCs. The error bars indicate the standard deviations.