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. 2011 Jul;85(14):7363–7371. doi: 10.1128/JVI.00098-11

Fig. 1.

Fig. 1.

Schematic representation of the genomic structure of oncolytic recombinant viruses OSV and OSVP. (A) Representation of the prototypic arrangement of the HSV-1 OncSyn (OS) genome with the unique long (UL) and unique short (US) regions flanked by the terminal repeat (TR) regions. The Δ denotes the approximate location of the OS genomic deletion between the UL and US regions (26), and the position of the gB syncytial mutation is indicated. The expanded area below the depicted genome shows the genomic region from 84531 to 96068 nucleotides encompassing the UL38-UL43 genes. (B) Genomic organization of the OSV recombinant virus showing deletion of the UL41 gene. (C) Genomic organization of the OSVP recombinant virus showing insertion of the 15-PGDH gene cassette in place of the deleted UL41 sequences. SV40, simian virus 40.