Skip to main content
. 2011 Jul;85(14):6913–6922. doi: 10.1128/JVI.00458-11

Fig. 2.

Fig. 2.

Seizure (Racine scale stages 3 to 5) frequency in chimeric mice. Chimeric mice, generated as described in Materials and Methods, were infected at 3 months of age with DA virus and monitored for the development of seizures. Significantly fewer irradiated 3-month-old IL-6-deficient chimeric mice reconstituted with wild-type donor cells (WT to IL-6−/−; 25%) had seizures compared to 3-month-old control mice (65%). Significantly fewer 5-week-old IL-6-deficient mice (IL-6−/−; 12.2%) and irradiated 3-month-old wild-type chimeric mice reconstituted with IL-6-deficient donor cells (IL-6−/− to WT; 16.7%) had seizures compared to 5-week-old control mice (51.4%), 3-month-old control mice (65%), and irradiated 3-month-old wild-type chimeric mice reconstituted with wild-type donor cells (WT to WT; 50%). ‡, P < 0.05; *, P < 0.01; †, P < 0.001; **, P < 0.0001 (chi-square test). The total number of mice infected (N) is shown over the individual bars of the graph. The percentages of mice with seizures (y axis) are calculated as follows: (no. of mice with seizures/total no. of mice infected) × 100.