Table 2.
Relative mRNA expression levels of chemokines (ligands and receptors) that affect multiple cell typesa
| Ligand or receptor | Other name | Relative mRNA expression in groupb: |
|||
|---|---|---|---|---|---|
| TMEV infected/PBS (day 2 p.i.) | Day 6 p.i. |
||||
| Seizures/PBS | No seizures/PBS | Seizures/no seizures | |||
| PMN and monocyte/macrophage recruitment | |||||
| CCL1 | I-309 | 1.6 | 2.2 | 1.0 | 2.1 |
| CCR8 | 1.6 | 4.2 | 1.5 | 2.7 | |
| CXCL4 | PF-4 | −1.5 | −2.6 | −1.6 | −1.6 |
| PMN recruitment and affects NK cells | |||||
| CCL20 | MIP-3α | 1.6 | 1.0 | −2.6 | 2.7 |
| Monocyte/macrophage recruitment and affects NK cells | |||||
| CCL6 | MRP-1 | 1.5 | 2.4 | 1.6 | 1.5 |
| CXCL10 | IP-10 | 637.1 | 1,266.0 | 837.5 | 1.5 |
| CCL19 | MIP-3β | 2.1 | 3.5 | 5.2 | −1.5 |
| CXCL12 | SDF-1 | −1.1 | −2.1 | −1.1 | −1.9 |
| CX3CL1 | C3Xkine | −1.1 | −1.7 | 1.6 | −2.8 |
| CCR7 | 1.6 | 11.3 | 3.4 | 3.4 | |
| PMN and monocyte/macrophage recruitment and affects NK cells | |||||
| CCL2 | MCP-1 | 208.3 | 453.8 | 72.5 | 6.3 |
| CCL4 | MIP-1β | 10.8 | 105.9 | 85.0 | 1.2 |
| CCL3 | MIP-1α | 6.8 | 16.4 | 12.9 | 1.3 |
| CCL5 | RANTES | 19.2 | 122.5 | 122.8 | −1.0 |
| CCL7 | MCP-3 | 43.8 | 186.9 | 99.0 | 1.9 |
| CCL8 | MCP-2 | 5.9 | 31.0 | 19.0 | 1.6 |
| CCL22 | MDC | 1.2 | 1.7 | 2.2 | −1.3 |
| CCR1 | 2.5 | 19.1 | 4.9 | 3.9 | |
| CCR2 | 6.1 | 26.3 | 2.4 | 11.2 | |
| CCR5 | 2.4 | 12.8 | 1.6 | 7.8 | |
| CCR4 | 1.6 | 1.9 | −2.2 | 4.1 | |
| CXCR3 | −1.4 | 38.5 | 79.9 | −2.1 | |
CCL, chemokine (C-C motif) ligand; CCR, chemokine (C-C motif) receptor; CX3CL, chemokine (C-X3-C motif) ligand; CXCL, chemokine (C-X-C motif) ligand; CXCR, chemokine (C-X-C motif) receptor; IP-10, IFN-γ-inducible protein 10; MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; MIP, macrophage inflammatory protein; MRP-1, MIP-related protein 1; NK, natural killer; PBS, phosphate-buffered saline; PF-4, platelet factor 4; p.i., postinfection; PMN, polymorphonuclear leukocyte; RANTES, regulated on activation, normal T-cell expressed and secreted; SDF-1, stromal cell-derived factor 1; TMEV, Theiler's murine encephalomyelitis virus.
mRNA expression normalized to normal-brain control group.