Table 3.
IC50s of E2-derived peptides
| HIV strain | Tropism | Clade | IC50 (μM) of peptide: |
|||||
|---|---|---|---|---|---|---|---|---|
| VIR-576 | P4-7 | P5 | P6-2 | P4762 | P28 | |||
| 92UG029 | X4 | A | NDa | 0.76 | 5.05 | 1.44 | 0.85 | ND |
| NL4-3 | X4 | B | 0.11 | 3.01 | 5.72 | 2.30 | 1.03 | >100 |
| SF33 | X4 | B | ND | 10.21 | 3.84 | 0.96 | 1.92 | ND |
| YU-2 | R5 | B | 0.55 | 5.21 | 7.30 | 2.39 | 1.97 | >100 |
| JRCSF | R5 | B | ND | 98.68 | 85.08 | >100 | >100 | ND |
| 92TH026 | R5 | B | ND | >100 | >100 | >100 | >100 | ND |
| 92BR025 | R5 | C | ND | >100 | >100 | >100 | >100 | ND |
| 92UG035 | R5 | D2 | ND | >100 | >100 | >100 | >100 | ND |
| 92UG024 | X4 | D3 | 0.31 | 0.33 | 0.71 | 0.08 | 0.13 | >100 |
| 93BR029 | R5 | F1 | ND | >100 | >100 | >100 | >100 | ND |
| 93BR020 | X4 | F2 | ND | >100 | 94.35 | >100 | 20.78 | ND |
| RU570 | R5 | G | 21.82 | 0.74 | 1.96 | 0.58 | 0.09 | >100 |
| V1557 | X4/R5 | H | ND | 72.23 | 80.54 | >100 | >100 | ND |
| SIVmac251 | >100 | >100 | >100 | >100 | >100 | ND | ||
| HIV-2 | >100 | >100 | >100 | >100 | >100 | ND | ||
a
ND, not determined.