Table 1.
CSFV E1 Cys-to-Ser mutant viruses rescued from SK6 cells and their virulence phenotype in infected swine
| Rescued mutant virus | Substituted Cys residue(s) | Phenotype |
|---|---|---|
| E1ΔCys5v | 5 | Virulent |
| E1ΔCys20v | 20 | Virulent |
| E1ΔCys24v | 24 | Virulent |
| E1ΔCys94v | 94 | Virulent |
| E1ΔCys123v | 123 | Virulent |
| E1ΔCys171v | 171 | Virulent |
| −a | 5/20 | − |
| − | 5/24 | − |
| − | 5/94 | − |
| − | 5/123 | − |
| E1ΔCys5/171v | 5/171 | Virulent |
| − | 20/24 | − |
| − | 20/94 | − |
| − | 20/123 | − |
| E1ΔCys20/171v | 20/171 | Virulent |
| E1ΔCys24/94v | 24/94 | Attenuated |
| − | 24/123 | − |
| − | 24/171 | − |
| − | 94/123 | − |
| E1ΔCys94/171v | 94/171 | Virulent |
| − | 123/171 | − |
a
−, no virus rescued.