Table 4.
Replication in the Malmo Diet and Cancer Study
| Model | Isoleucine | Leucine | Valine | Tyrosine | Phenylalanine | Isoleucine, tyrosine, and phenylalanine |
|---|---|---|---|---|---|---|
| Metabolite as continuous variable | ||||||
| Per SD | 1.37 (0.95-1.96) | 1.60 (1.13-2.27) | 2.01 (1.18-3.42) | 1.41 (1.05-1.91) | 1.37 (1.01-1.84) | 1.52 (1.10-2.11) |
| P | 0.09 | 0.009 | 0.01 | 0.02 | 0.04 | 0.01 |
| Metabolite as categorical variable | ||||||
| 1st quartile | 1.0 (referent) | 1.0 (referent) | 1.0 (referent) | 1.0 (referent) | 1.0 (referent) | 1.0 (referent) |
| 2nd quartile | 1.02 (0.53-1.98) | 1.97 (0.86-4.54) | 2.11 (0.99-4.48) | 1.92 (0.92-4.01) | 2.37 (1.08-5.16) | 2.08 (0.97-4.46) |
| 3rd quartile | 1.62 (0.77-3.42) | 2.53 (1.09-5.87) | 1.82 (0.59-5.65) | 2.17 (1.03-4.57) | 4.30 (1.87-9.88) | 2.59 (1.09-6.15) |
| 4th quartile | 2.37 (0.97-5.81) | 3.81 (1.39-10.46) | 2.85 (0.77-10.51) | 3.16 (1.31-7.59) | 3.04 (1.20-7.70) | 3.93 (1.54-10.04) |
| P for trend | 0.05 | 0.01 | 0.09 | 0.01 | 0.007 | 0.006 |
Values are odds ratios (95% confidence intervals) for diabetes, from conditional logistic regressions. All models are adjusted for age, sex, BMI, and fasting glucose. The amino acid combination is modeled according to the formula β1X1 + β2X2 + β3X3, with Xj denoting the standardized value for the jth amino acid, and βj denoting the regression coefficient from the conditional logistic regression model containing the indicated metabolites.