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MBD2 and NuRD copurify with a methyl-CpG-binding activity as a 1MD protein complex. (A) Western blot analysis of fractions derived from a gel filtration Superose-6 column. The elution profiles of the protein size markers and the proteins analyzed are indicated. (B,C) Gel mobility shift assays using the same fractions as in panel A. The probes used in panels B and C are methylated and nonmethylated, respectively. Methylation-dependent shift and free probes are indicated.
