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IC50 values for FAAH inhibition by PF-04457845 with various preincubation times
The IC50 values were obtained in the 384-well format assay as described under Materials and Methods. Values are averages ± S.D. from three experiments.
| Preincubation time | IC50 |
|
|---|---|---|
| hFAAH | rFAAH | |
| min | nM | |
| 1 | 50.4 ± 5.5 | 43.1 ± 2.3 |
| 15 | 32.4 ± 0.99 | 26.7 ± 1.5 |
| 30 | 10.7 ± 1.0 | 11.1 ± 0.55 |
| 60 | 7.2 ± 0.63 | 7.4 ± 0.62 |
