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Seven-week hyperglycemia decreased the expression of both α3 and β1 integrins, which attach the podocytes to the GBM. Both ET receptor antagonists significantly increased the expression of α3 integrin compared with the control hyperglycemic glomerular levels; however, neither ET receptor antagonist had an effect on the expression of β1 integrin. *, p < 0.05 versus sham; †, p < 0.05 versus HG.
