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Hyperglycemia induction increased both total MMP activity (A) and active TGF-β1 (B) in glomeruli after 7 weeks of established hyperglycemia. Both ET receptor antagonists significantly reduced these changes. However, the attenuation effect of the mixed antagonist on active TGF-β1 remained significantly higher compared with ETA receptor-selective blockade. *, p < 0.05 versus sham; †, p < 0.05 versus HG; §, p < 0.05 versus HG + ABT-627.
