Fig. 5.
A, glomerular sICAM-1 and MCP-1 were significantly increased after 7 weeks of established hyperglycemia. Selective ETA receptor antagonism significantly reduced the elevated inflammatory protein levels. Nonselective ET receptor antagonists did not have any effect on glomerular sICAM-1 and MCP-1, indicating the counteracting effects of the ETA receptor and ETB receptor in hyperglycemia-induced inflammation. B, plasma concentrations of inflammatory molecules, sICAM-1 and MCP-1, were significantly increased after 7 weeks of established hyperglycemia. Selective ETA receptor antagonism significantly reduced the elevated sICAM-1 but not MCP-1 in HG rats. Nonselective ET receptor antagonists did not have any effect on plasma sICAM-1 (or MCP-1), suggesting a counteracting effect of the ETA receptor and ETB receptor in hyperglycemia-induced inflammation. *, p < 0.05 versus sham; †, p < 0.05 versus HG; §, p < 0.05 versus HG + ABT-627.