TABLE 1.
Characteristics of experimental animals after 6 weeks of STZ-induced diabetes (pretreatment) and after 1 week of treatment with ET receptor antagonists (post-treatment)
Data are means ± S.E.M. (n = 6 in sham and sham-treated groups and n = 10 in HG and HG-treated groups). Urine flow data were derived from 24-h urine collections in metabolic cages.
| Body Weight |
Glycemia |
Food Intake |
Water Intake |
Urine Flow |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pretreatment | Post-Treatment | Pretreatment | Post-Treatment | Pretreatment | Post-Treatment | Pretreatment | Post-Treatment | Pretreatment | Post-Treatment | |
| g | mg/dl | g | ml | |||||||
| Sham | 369 ± 1 | 380 ± 1 | 102 ± 8 | 109 ± 5 | 25 ± 2 | 33 ± 2 | 32 ± 1 | 28 ± 3 | 14 ± 1 | 18 ± 1 |
| Sham + ABT-672 | 369 ± 1 | 382 ± 2 | 95 ± 4 | 106 ± 3 | 27 ± 1 | 30 ± 2 | 34 ± 3 | 32 ± 2 | 15 ± 1 | 20 ± 1 |
| Sham + A-182086 | 370 ± 2 | 386 ± 2 | 98 ± 1 | 108 ± 2 | 25 ± 1 | 28 ± 2 | 31 ± 3 | 29 ± 3 | 14 ± 1 | 20 ± 1 |
| HG | 320 ± 4* | 326 ± 3* | 569 ± 9* | 566 ± 16* | 48 ± 2* | 54 ± 2* | 240 ± 3* | 235 ± 3* | 220 ± 3* | 222 ± 4* |
| HG + ABT-627 | 319 ± 3 | 323 ± 2 | 567 ± 11 | 594 ± 4 | 52 ± 2 | 53 ± 2 | 247 ± 3 | 237 ± 3 | 221 ± 4 | 213 ± 2 |
| HG + A-182086 | 312 ± 2 | 317 ± 2 | 577 ± 6 | 589 ± 3 | 56 ± 2 | 51 ± 2 | 246 ± 4 | 234 ± 3 | 205 ± 4 | 213 ± 4 |
*
p < 0.05 versus sham group.